Use of a racemic derivatizing agent for measurement of enantiomeric excess by circular dichroism spectroscopy

Tetsutaro Hattori, Yuji Minato, Sulan Yao, M. G. Finn, Sotaro Miyano

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Enantiomeric excesses of several alcohols and an amine have been determined by derivatization with racemic 2′-methoxy-1,1′-binaphthyl-2-carbonyl chloride rac-1, with no requirement for kinetic resolution in the acylation step. The necessary information is provided instead by CD and UV spectra of the derived esters and amides, the chiral signal being dominated by the binaphthyl component.

Original languageEnglish
Pages (from-to)8015-8018
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number45
DOIs
Publication statusPublished - 2001 Nov 5

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Use of a racemic derivatizing agent for measurement of enantiomeric excess by circular dichroism spectroscopy'. Together they form a unique fingerprint.

  • Cite this