Urine levels of defensin α1 reflect kidney injury in leptospirosis patients

Haorile Chagan-Yasutan, Yue Chen, Talitha Lea Lacuesta, Prisca Susan A. Leano, Hiroko Iwasaki, Firmanto Hanan, Delsi Taurustiati, Yasukazu Ohmoto, Yugo Ashino, Hiroki Saitoh, Hideyasu Kiyomoto, Yasuhiko Suzuki, Freda O.Elizabeth Telan, Toshio Hattori

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4 Citations (Scopus)

Abstract

Leptospirosis is a zoonotic disease whose severe forms are often accompanied by kidney dysfunction. In the present study, urinary markers were studied for potential prediction of disease severity. Urine samples from 135 patients with or without leptospirosis at San Lazaro Hospital, the Philippines, were analyzed. Urine levels of defensin α1 (uDA1) were compared with those of neutrophil gelatinase-associated lipocalin (uNGAL) and N-acetyl-β-D-glucosidase (uNAG). Serum creatinine (Cr) was used as a marker of kidney injury. The levels of uDA1/Cr, uNGAL/Cr, and uNAG/Cr were positive in 46%, 90%, and 80% of leptospirosis patients, and 69%, 70%, and 70% of non-leptospirosis patients, respectively. In leptospirosis patients, the correlation of uDA1/Cr, uNGAL/Cr and uNAG/Cr levels with serum Cr were r = 0.3 (p < 0.01), r = 0.29 (p < 0.01), and r = 0.02 (p = 0.81), respectively. uDA1/Cr levels were correlated with uNGAL/Cr levels (r = 0.49, p < 0.01) and uNAG/Cr levels (r = 0.47, p < 0.0001) in leptospirosis patients. These findings suggest that uDA1, uNGAL, and uNAG were elevated in leptospirosis patients and reflected various types of kidney damage. uDA1 and uNGAL can be used to track kidney injury in leptospirosis patients because of their correlation with the serum Cr level.

Original languageEnglish
Article number1637
JournalInternational journal of molecular sciences
Volume17
Issue number10
DOIs
Publication statusPublished - 2016 Oct 1

Keywords

  • Defensin α1
  • Kidney injury
  • Leptospirosis
  • N-acetyl-β-D-glucosidase (NAG)
  • Neutrophil gelatinase-associated lipocalin (NGAL)

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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  • Cite this

    Chagan-Yasutan, H., Chen, Y., Lacuesta, T. L., Leano, P. S. A., Iwasaki, H., Hanan, F., Taurustiati, D., Ohmoto, Y., Ashino, Y., Saitoh, H., Kiyomoto, H., Suzuki, Y., Telan, F. O. E., & Hattori, T. (2016). Urine levels of defensin α1 reflect kidney injury in leptospirosis patients. International journal of molecular sciences, 17(10), [1637]. https://doi.org/10.3390/ijms17101637