Urinary polyamine evaluation for effective diagnosis of various cancers

Ja Won Suh, Seon Hwa Lee, Bong Chul Chung, Jongsei Park

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

With a newly modified analytical method, the concentrations of free and acetylated urinary polyamines were simultaneously determined in a control group (32 cases) and patients with various types of cancers (104 cases, 20 males and 84 females) by gas chromatography-nitrogen-phosphorus detection. Significant concentration differences between normal subjects and various cancer patients were found. The various types of cancers (advanced gastric carcinoma, ovarian cancer, acute myelocyte leukemia, non-Hodgkin's lymphoma) gave unique patterns of urinary polyamine profile as well as significant differences of concentration. To indirectly evaluate the possible involvement of enzymes, precursor-to-product concentration ratios were compared between controls and patients with various types of cancers.

Original languageEnglish
Pages (from-to)179-186
Number of pages8
JournalJournal of Chromatography B: Biomedical Applications
Volume688
Issue number2
DOIs
Publication statusPublished - 1997 Jan 24
Externally publishedYes

Keywords

  • N-Acetylputrescine
  • Polyamines
  • Putrescine
  • Spermidine
  • Spermine

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Urinary polyamine evaluation for effective diagnosis of various cancers'. Together they form a unique fingerprint.

Cite this