Urinary excretion of vascular endothelial growth factor is increased in children with reflux nephropathy

Ryuichiro Konda, Hiroshi Sato, Kiyohide Sakai, Yuko Abe, Tomoaki Fujioka

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background: We determined the urinary levels of vascular endothelial growth factor (VEGF) in patients with reflux nephropathy to elucidate its clinical significance as a predictor of the development of renal damage. Patients and Methods: Seventy-two patients (47 boys and 25 girls) aged 10-18 years with reflux nephropathy were studied. Vesicoureteral reflux was resolved surgically in all cases at least 2 years before enrollment. Urinary VEGF, α1-microglobulin and albumin levels were determined using morning spot urine samples. Plasma VEGF, serum creatinine and β2-microglobulin levels were measured simultaneously. The severity of renal scarring and right and left kidney function were assessed by 99mTc dimercaptosuccinic acid renal scan. Results: No significant correlation was found between the plasma and urinary VEGF levels. Urinary VEGF increased significantly with the increase in severity of renal scarring (p < 0.0001). Urinary VEGF levels correlated significantly with serum β2-microglobulin (p < 0.002) and urinary α1- microglobulin (p < 0.03). No significant correlation of urinary VEGF levels with serum creatinine and urinary albumin levels was found. Nearly 60% of the patients with elevated urinary VEGF had normal levels of serum β2-microglobulin and/or urinary α1- miocroglobulin. Conclusions: Urinary VEGF level appears to reflect its production in the kidney. Since urinary VEGF shows a propensity to elevate before the increase in serum β2-microglobulin and/or urinary α1-microglobulin, urinary VEGF may serve as an early indicator of the development of reflux nephropathy.

Original languageEnglish
Pages (from-to)c73-c78
JournalNephron - Clinical Practice
Volume98
Issue number3
DOIs
Publication statusPublished - 2004

Keywords

  • Albumin
  • Kidney
  • Reflux nephropathy
  • Vascular endothelial growth factor
  • Vesicoureteral reflux
  • α-Microglobulin

ASJC Scopus subject areas

  • Nephrology

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