Urinary angiotensinogen excretion is associated with blood pressure in obese young adults

Emiko Sato, Takefumi Mori, Michihiro Satoh, Mutsuko Fujiwara, Yoshimi Nakamichi, Ikuko Oba, Susumu Ogawa, Yoshitaka Kinouchi, Hiroshi Sato, Sadayoshi Ito, Wataru Hida

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Intrarenal RAS has been suggested to be involved in the pathogenesis of hypertension. It was recently reported that urinary angiotensinogen excretion levels are associated with intrarenal RAS. However, few markers predicting intrarenal RAS have been investigated in obese young subjects. The present study evaluated the association between blood pressure and intrarenal RAS activity, inflammation and oxidative stress in obese young adults. Urinary angiotensinogen excretion and urinary monocyte chemotactic protein (MCP)-1, and urinary thiobarbituric acid reaction substance (TBARS) as markers of intrarenal RAS activity, inflammation, and oxidative stress, respectively, were determined from morning urine of 111 young male adults. Participants were divided into two groups based on the body mass index (BMI). Natural log-transformed urinary angiotensinogen excretion level was significantly associated with blood pressure, MCP-1 excretion, and TBARS excretion elevation in the obese group (BMI ≥25 kg/m2). Multivariable analyses showed that every 1 standard deviation increase in natural-log transformed urinary angiotensinogen and MCP-1 excretion, but not TBARS excretion level was associated with elevated blood pressure in the obese group. These results indicate that urinary angiotensinogen and MCP-1 excretion were associated with blood pressure elevation in this population of obese young adults. It suggested that inappropriate RAS activity and inflammation precedes hypertension in obese young subjects and urinary angiotensinogen could be a screening maker for hypertension in young obese subjects.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalClinical and Experimental Hypertension
Volume38
Issue number2
DOIs
Publication statusPublished - 2016 Feb 17

Keywords

  • Angiotensinogen
  • blood pressure
  • intrarenal renin-angiotensin system
  • obese young adults
  • urinary biomarker

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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