Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma

Hitoshi Miyashita, Yuji Takebayashi, James F. Eliason, Fumihiro Fujimori, Yasutaka Nitta, Atsushi Sato, Hidehiro Morikawa, Akira Ohashi, Katutoshi Motegi, Manabu Fukumoto, Shiro Mori, Takafumi Uchida

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

BACKGROUND. Uridine phosphorylase (UPase) catalyzes the reversible phosphorolysis of uridine to uracil. The expression levels and the enzymatic activity of UPase are reported to be higher in human solid tumors than in adjacent normal tissues. However, to the authors' knowledge the clinical significance of UPase expression as determined by immunohistochemical analysis has not been demonstrated in human malignancies. METHODS. The authors prepared the antibody against UPase, examined the staining of UPase in 72 cases of oral squamous cell carcinoma (SCC) with immunohistochemical analysis using the antibody, and analyzed its relation to clinical and pathologic factors. RESULTS. UPase stained mainly within the invasive edges of tumors and macrophages. UPase-positive staining was observed in 56 of the 72 tumors (77.8%). High staining of UPase (defined as > 50% of cells in a tumor biopsy that are positive for UPase) in primary tumors frequently was associated with the presence of metastasis to lymph nodes (P = 0.007 by the Fischer exact test) and with lower overall survival (P = 0.03 by the log-rank test). CONCLUSIONS. The high rate of UPase staining in biopsies from patients with oral SCC may be a prognostic marker for these individuals.

Original languageEnglish
Pages (from-to)2959-2966
Number of pages8
JournalCancer
Volume94
Issue number11
DOIs
Publication statusPublished - 2002 Jun 1

Keywords

  • Lymph node metastasis
  • Oral squamous cell carcinoma (SCC)
  • Prognosis
  • Uridine phosphorylase (UPase)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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