Urea Sensor Based on an Ion-Sensitive Field Effect Transistor. IV. Determination of Urea in Human Blood

Jun Ichi Anza; Sachmo Tezuka; Tetsuo Osa; Hideki Nakajima; Tadayuki Matsuo

doi:10.1248/cpb.35.693

Urea Sensor Based on an Ion-Sensitive Field Effect Transistor. IV. Determination of Urea in Human Blood

Jun Ichi Anza, Sachmo Tezuka, Tetsuo Osa, Hideki Nakajima, Tadayuki Matsuo

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A potentiometric method for the determination of urea in human blood with an ion-sensitive field effect transistor coated with a urease-albumin membrane is described. The urea sensor exhibits a potentiometric response to urea concentrations in the range of 0.1—10 mm with a response time of ca. 3 min. Urea concentrations of diluted serum and plasma can be determined accurately with the sensor. Comparison with an official method (i.e. the urease-indophenol method) gave satisfactory results.

Original language	English
Pages (from-to)	693-698
Number of pages	6
Journal	Chemical and Pharmaceutical Bulletin
Volume	35
Issue number	2
DOIs	https://doi.org/10.1248/cpb.35.693
Publication status	Published - 1987

Keywords

enzyme sensor
human blood
ion-sensitive field effect transistor
urea sensor
urease

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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abstract = "A potentiometric method for the determination of urea in human blood with an ion-sensitive field effect transistor coated with a urease-albumin membrane is described. The urea sensor exhibits a potentiometric response to urea concentrations in the range of 0.1—10 mm with a response time of ca. 3 min. Urea concentrations of diluted serum and plasma can be determined accurately with the sensor. Comparison with an official method (i.e. the urease-indophenol method) gave satisfactory results.",

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AU - Tezuka, Sachmo

AU - Osa, Tetsuo

AU - Nakajima, Hideki

AU - Matsuo, Tadayuki

PY - 1987

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AB - A potentiometric method for the determination of urea in human blood with an ion-sensitive field effect transistor coated with a urease-albumin membrane is described. The urea sensor exhibits a potentiometric response to urea concentrations in the range of 0.1—10 mm with a response time of ca. 3 min. Urea concentrations of diluted serum and plasma can be determined accurately with the sensor. Comparison with an official method (i.e. the urease-indophenol method) gave satisfactory results.

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KW - human blood

KW - ion-sensitive field effect transistor

KW - urea sensor

KW - urease

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