Urea Sensor Based on an Ion-Sensitive Field Effect Transistor. IV. Determination of Urea in Human Blood

Jun Ichi Anza, Sachmo Tezuka, Tetsuo Osa, Hideki Nakajima, Tadayuki Matsuo

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

A potentiometric method for the determination of urea in human blood with an ion-sensitive field effect transistor coated with a urease-albumin membrane is described. The urea sensor exhibits a potentiometric response to urea concentrations in the range of 0.1—10 mm with a response time of ca. 3 min. Urea concentrations of diluted serum and plasma can be determined accurately with the sensor. Comparison with an official method (i.e. the urease-indophenol method) gave satisfactory results.

Original languageEnglish
Pages (from-to)693-698
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume35
Issue number2
DOIs
Publication statusPublished - 1987

Keywords

  • enzyme sensor
  • human blood
  • ion-sensitive field effect transistor
  • urea sensor
  • urease

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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