Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction

A. C. Collier, K. A. Milam, L. R.A. Rougée, A. Sugawara, Y. Yamauchi, M. A. Ward

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1, 1a2, 1a6 and 1a9 expression in murine placentas and fetal livers with higher mRNA related to lower progesterone (1a1) and cholesterol (1a2, 1a6) in placentas. Greater steroid clearance in ART through transcriptional upregulation of Ugt1a in the placental-fetal unit may decrease the availability of essential molecules, mediating negative reproductive outcomes.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalPlacenta
Volume33
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1
Externally publishedYes

Keywords

  • Assisted reproduction
  • Detoxification
  • Endocrinology
  • Placenta
  • Pregnancy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Developmental Biology

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