Update on endogenous inhibitors of angiogenesis

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32 Citations (Scopus)


Angiogenesis is regulated by a local balance between the levels of endogenous stimulators and inhibitors of angiogenesis. Understanding of the mechanism of angiogenesis has advanced significantly since the discovery of two members of the family of angiogenesis stimulators, i.e., vascular endothelial growth factor family proteins and angiopoietins. These factors act on endothelial cells to stimulate angiogenesis. In contrast, most of angiogenesis inhibitors do not seem to have such characteristics. Very few genes encoding molecules that selectively inhibit angiogenesis have been discovered. This review will focus on our current understanding of endogenous inhibitors of angiogenesis.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalEndothelium: Journal of Endothelial Cell Research
Issue number2
Publication statusPublished - 2006 Mar


  • Angiogenesis inhibitor
  • Degradation products
  • Gene products
  • Metabolites

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


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