Abstract
To investigate the role of claudin-6 in adipogenesis, claudin-6 mRNA was examined in adipose tissues and adipocyte differentiation. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet as compared to a normal-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 cells in vitro. Moreover, small interfering RNA (siRNA)-mediated reduction of claudin-6 mRNA inhibited differentiation of 3T3-L1 cells. These results suggest that claudin-6 is another important regulator in adipogenesis and fat deposition.
Original language | English |
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Pages (from-to) | 2117-2121 |
Number of pages | 5 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 69 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2005 |
Externally published | Yes |
Keywords
- Adipogenesis
- Adipose tissue
- Claudin-6
- Fat depot
- High-fat diet
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry