Up-regulation of the claudin-6 gene in adipogenesis

Yeon Hee Hong, Daisuke Hishikawa, Hisae Miyahara, Yukihiko Nishimura, Hiroaki Tsuzuki, Chizu Gotoh, Tomoyo Iga, Yasuki Suzuki, Sang Houn Song, Ki Choon Choi, Hong Gu Lee, Shinichi Sasaki, Sang Gun Roh

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


To investigate the role of claudin-6 in adipogenesis, claudin-6 mRNA was examined in adipose tissues and adipocyte differentiation. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet as compared to a normal-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 cells in vitro. Moreover, small interfering RNA (siRNA)-mediated reduction of claudin-6 mRNA inhibited differentiation of 3T3-L1 cells. These results suggest that claudin-6 is another important regulator in adipogenesis and fat deposition.

Original languageEnglish
Pages (from-to)2117-2121
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Issue number11
Publication statusPublished - 2005
Externally publishedYes


  • Adipogenesis
  • Adipose tissue
  • Claudin-6
  • Fat depot
  • High-fat diet

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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