Up-regulation of the claudin-6 gene in adipogenesis

Yeon Hee Hong; Daisuke Hishikawa; Hisae Miyahara; Yukihiko Nishimura; Hiroaki Tsuzuki; Chizu Gotoh; Tomoyo Iga; Yasuki Suzuki; Sang Houn Song; Ki Choon Choi; Hong Gu Lee; Shinichi Sasaki; Sang Gun Roh

doi:10.1271/bbb.69.2117

Up-regulation of the claudin-6 gene in adipogenesis

Yeon Hee Hong, Daisuke Hishikawa, Hisae Miyahara, Yukihiko Nishimura, Hiroaki Tsuzuki, Chizu Gotoh, Tomoyo Iga, Yasuki Suzuki, Sang Houn Song, Ki Choon Choi, Hong Gu Lee, Shinichi Sasaki, Sang Gun Roh

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

To investigate the role of claudin-6 in adipogenesis, claudin-6 mRNA was examined in adipose tissues and adipocyte differentiation. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet as compared to a normal-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 cells in vitro. Moreover, small interfering RNA (siRNA)-mediated reduction of claudin-6 mRNA inhibited differentiation of 3T3-L1 cells. These results suggest that claudin-6 is another important regulator in adipogenesis and fat deposition.

Original language	English
Pages (from-to)	2117-2121
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	69
Issue number	11
DOIs	https://doi.org/10.1271/bbb.69.2117
Publication status	Published - 2005
Externally published	Yes

Keywords

Adipogenesis
Adipose tissue
Claudin-6
Fat depot
High-fat diet

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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Hong, Y. H., Hishikawa, D., Miyahara, H., Nishimura, Y., Tsuzuki, H., Gotoh, C., Iga, T., Suzuki, Y., Song, S. H., Choi, K. C., Lee, H. G., Sasaki, S., & Roh, S. G. (2005). Up-regulation of the claudin-6 gene in adipogenesis. Bioscience, Biotechnology and Biochemistry, 69(11), 2117-2121. https://doi.org/10.1271/bbb.69.2117

Up-regulation of the claudin-6 gene in adipogenesis. / Hong, Yeon Hee; Hishikawa, Daisuke; Miyahara, Hisae; Nishimura, Yukihiko; Tsuzuki, Hiroaki; Gotoh, Chizu; Iga, Tomoyo; Suzuki, Yasuki; Song, Sang Houn; Choi, Ki Choon; Lee, Hong Gu; Sasaki, Shinichi; Roh, Sang Gun.

In: Bioscience, Biotechnology and Biochemistry, Vol. 69, No. 11, 2005, p. 2117-2121.

Research output: Contribution to journal › Article

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abstract = "To investigate the role of claudin-6 in adipogenesis, claudin-6 mRNA was examined in adipose tissues and adipocyte differentiation. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet as compared to a normal-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 cells in vitro. Moreover, small interfering RNA (siRNA)-mediated reduction of claudin-6 mRNA inhibited differentiation of 3T3-L1 cells. These results suggest that claudin-6 is another important regulator in adipogenesis and fat deposition.",

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