Up-regulation of the claudin-6 gene in adipogenesis

Yeon Hee Hong; Daisuke Hishikawa; Hisae Miyahara; Yukihiko Nishimura; Hiroaki Tsuzuki; Chizu Gotoh; Tomoyo Iga; Yasuki Suzuki; Sang Houn Song; Ki Choon Choi; Hong Gu Lee; Shinichi Sasaki; Sang Gun Roh

doi:10.1271/bbb.69.2117

Up-regulation of the claudin-6 gene in adipogenesis

Yeon Hee Hong, Daisuke Hishikawa, Hisae Miyahara, Yukihiko Nishimura, Hiroaki Tsuzuki, Chizu Gotoh, Tomoyo Iga, Yasuki Suzuki, Sang Houn Song, Ki Choon Choi, Hong Gu Lee, Shinichi Sasaki, Sang Gun Roh

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

To investigate the role of claudin-6 in adipogenesis, claudin-6 mRNA was examined in adipose tissues and adipocyte differentiation. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet as compared to a normal-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 cells in vitro. Moreover, small interfering RNA (siRNA)-mediated reduction of claudin-6 mRNA inhibited differentiation of 3T3-L1 cells. These results suggest that claudin-6 is another important regulator in adipogenesis and fat deposition.

Original language	English
Pages (from-to)	2117-2121
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	69
Issue number	11
DOIs	https://doi.org/10.1271/bbb.69.2117
Publication status	Published - 2005
Externally published	Yes

Keywords

Adipogenesis
Adipose tissue
Claudin-6
Fat depot
High-fat diet

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.69.2117

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Up-regulation of the claudin-6 gene in adipogenesis. / Hong, Yeon Hee; Hishikawa, Daisuke; Miyahara, Hisae; Nishimura, Yukihiko; Tsuzuki, Hiroaki; Gotoh, Chizu; Iga, Tomoyo; Suzuki, Yasuki; Song, Sang Houn; Choi, Ki Choon; Lee, Hong Gu; Sasaki, Shinichi; Roh, Sang Gun.

In: Bioscience, Biotechnology and Biochemistry, Vol. 69, No. 11, 2005, p. 2117-2121.

Research output: Contribution to journal › Article › peer-review

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title = "Up-regulation of the claudin-6 gene in adipogenesis",

abstract = "To investigate the role of claudin-6 in adipogenesis, claudin-6 mRNA was examined in adipose tissues and adipocyte differentiation. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet as compared to a normal-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 cells in vitro. Moreover, small interfering RNA (siRNA)-mediated reduction of claudin-6 mRNA inhibited differentiation of 3T3-L1 cells. These results suggest that claudin-6 is another important regulator in adipogenesis and fat deposition.",

keywords = "Adipogenesis, Adipose tissue, Claudin-6, Fat depot, High-fat diet",

author = "Hong, {Yeon Hee} and Daisuke Hishikawa and Hisae Miyahara and Yukihiko Nishimura and Hiroaki Tsuzuki and Chizu Gotoh and Tomoyo Iga and Yasuki Suzuki and Song, {Sang Houn} and Choi, {Ki Choon} and Lee, {Hong Gu} and Shinichi Sasaki and Roh, {Sang Gun}",

note = "Funding Information: This work was supported in part by a Grant-in-Aid (no. 17380168 to S.-G. R.) for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.",

year = "2005",

doi = "10.1271/bbb.69.2117",

language = "English",

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AU - Hong, Yeon Hee

AU - Hishikawa, Daisuke

AU - Miyahara, Hisae

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AU - Tsuzuki, Hiroaki

AU - Gotoh, Chizu

AU - Iga, Tomoyo

AU - Suzuki, Yasuki

AU - Song, Sang Houn

AU - Choi, Ki Choon

AU - Lee, Hong Gu

AU - Sasaki, Shinichi

AU - Roh, Sang Gun

N1 - Funding Information: This work was supported in part by a Grant-in-Aid (no. 17380168 to S.-G. R.) for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2005

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N2 - To investigate the role of claudin-6 in adipogenesis, claudin-6 mRNA was examined in adipose tissues and adipocyte differentiation. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet as compared to a normal-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 cells in vitro. Moreover, small interfering RNA (siRNA)-mediated reduction of claudin-6 mRNA inhibited differentiation of 3T3-L1 cells. These results suggest that claudin-6 is another important regulator in adipogenesis and fat deposition.

AB - To investigate the role of claudin-6 in adipogenesis, claudin-6 mRNA was examined in adipose tissues and adipocyte differentiation. Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet as compared to a normal-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 cells in vitro. Moreover, small interfering RNA (siRNA)-mediated reduction of claudin-6 mRNA inhibited differentiation of 3T3-L1 cells. These results suggest that claudin-6 is another important regulator in adipogenesis and fat deposition.

KW - Adipogenesis

KW - Adipose tissue

KW - Claudin-6

KW - Fat depot

KW - High-fat diet

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Up-regulation of the claudin-6 gene in adipogenesis

Abstract

Keywords

ASJC Scopus subject areas

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