Up-regulation of CD11a (LFA-1) expression on peripheral CD4+ T cells in primary biliary cirrhosis

Masaaki Shiina, Koju Kobayashi, Yutaka Mano, Yoshiyuki Ueno, Motoyasu Ishii, Tooru Shimosegawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Up-regulation of CD11a expression on CD4+ T lymphocytes is considered to be one of the mechanisms involved in the initiation of the Th-1-mediated immune response. In this study, peripheral blood mononuclear cells from patients with primary biliary cirrhosis (PBC) were evaluated for CD11ahighCD2low T cells and populations of type 1 (Th-1) and type 2 (Th-2) helper T cells. CD11ahighCD2low T cells were found in PBC (7/15) and in active rheumatoid arthritis (4/4), but not in chronic hepatitis C (0/5) or in healthy subjects (0/6). The population of Th-1 had a positive correlation with that of CD4+CD11ahighCD2+ cells in patients with PBC (P = 0.034). The serum levels of interferon-γ also had a weak correlation with the population of CD4+CD11ahighCD2low cells (P = 0.050). There was no statistically significant correlation of Th-2 population (P = 0.295) or serum interleukin-4 level (P = 0.685) with the population of CD4+CD11ahighCD2low cells. These results suggest that CD4+CD11ahigh cells play a role in Th-1-predominance and in the autoimmune process of PBC.

Original languageEnglish
Pages (from-to)1209-1215
Number of pages7
JournalDigestive Diseases and Sciences
Volume47
Issue number6
DOIs
Publication statusPublished - 2002

Keywords

  • Interferon-γ
  • Lymphocyte function-associated antigen-1
  • Primary biliary cirrhosis
  • Th-1

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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