Unzipping and shearing DNA with electrophoresed nanoparticles in hydrogels

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3 Citations (Scopus)


We show electric control of unzipping and shearing dehybridization of a DNA duplex anchored to a hydrogel. Tensile force is applied by electrophoresing (25 V cm-1) gold nanoparticles pulling the DNA duplex. The pulled DNA strand is gradually released from the hydrogel. The unzipping release rate is faster than shearing; for example, 3-fold for a 15 base pair duplex, which helps to design electrically driven DNA devices.

Original languageEnglish
Pages (from-to)13414-13418
Number of pages5
JournalPhysical Chemistry Chemical Physics
Issue number21
Publication statusPublished - 2017

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry


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