Untangling tau imaging

Victor L. Villemagne, Nobuyuki Okamura, Christopher C. Rowe

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

In vivo imaging of tau deposits is providing a better understanding of the temporal and spatial tau deposition in the brain, allowing a more comprehensive insight into the causes, diagnoses, and potentially treatment of tauopathies such as Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of frontotemporal lobar degeneration. The assessment of tau deposition in the brain over time will allow a deeper understanding of the relationship between tau and other variables such as cognition, genotype, and neurodegeneration, as well as assessing the role tau plays in ageing. Preliminary human studies suggest that tau imaging could also be used as a diagnostic, prognostic, and theranostic biomarker, as well as a surrogate marker for target engagement, patient recruitment, and efficacy monitoring for disease-specific therapeutic trials.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume4
DOIs
Publication statusPublished - 2016

Keywords

  • Alzheimer's disease
  • Dementia
  • PET
  • Positron emission tomography
  • Tau imaging
  • Tauopathies

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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