TY - JOUR
T1 - Unique histopathological features of graft biopsies with liver function abnormalities in living donor liver transplant patients receiving basiliximab induction therapy
AU - Sato, Kazushige
AU - Sekiguchi, Satoshi
AU - Kawagishi, Naoki
AU - Akamatsu, Yorihiro
AU - Ishida, Kazuyuki
AU - Fukushima, Daizo
AU - Miyagi, Shigeto
AU - Takeda, Ikuo
AU - Yamaguchi, Masaaki
AU - Oguma, Shirou
AU - Fujimori, Keisei
AU - Sato, Akira
AU - Satomi, Susumu
PY - 2011/1
Y1 - 2011/1
N2 - Induction with basiliximab (BXM) has been confirmed as an effective treatment regimen for prophylaxis of acute cellular rejection (ACR). From 1991 to 2008, 116 living donor liver transplantations (LDLTs) were performed. Among these, 50 were included in this study. We compared calcineurin inhibitor plus steroid treatment without BXM (n=14, control group) and with BXM (n=36, BXM group). Although the rates of biopsied patients with abnormal serum biochemical tests (SBTs) were similar in the control (10/14, 71.4%) and BXM (21/36, 58.3%) groups, ACR was diagnosed in 9/10 (90.0%) patients in the control group compared with 4/21 (19.0%) patients in the BXM group. In accordance with the histopathological diagnosis, there was a significant difference in the ratios of peripheral CD4+CD25+ T cells at fivewk after LDLT between patients with and without ACR in the BXM group. Next, we divided the 32 patients without ACR in the BXM group into two groups: biopsied patients with abnormal SBTs and non-biopsied patients. The donor age of the biopsied patients was significantly higher than that of the non-biopsied patients. Induction with BXM reduced the incidence of ACR, and unique pathological phenomena responsible for graft dysfunction after LDLT with an increased incidence of abnormal SBTs were observed.
AB - Induction with basiliximab (BXM) has been confirmed as an effective treatment regimen for prophylaxis of acute cellular rejection (ACR). From 1991 to 2008, 116 living donor liver transplantations (LDLTs) were performed. Among these, 50 were included in this study. We compared calcineurin inhibitor plus steroid treatment without BXM (n=14, control group) and with BXM (n=36, BXM group). Although the rates of biopsied patients with abnormal serum biochemical tests (SBTs) were similar in the control (10/14, 71.4%) and BXM (21/36, 58.3%) groups, ACR was diagnosed in 9/10 (90.0%) patients in the control group compared with 4/21 (19.0%) patients in the BXM group. In accordance with the histopathological diagnosis, there was a significant difference in the ratios of peripheral CD4+CD25+ T cells at fivewk after LDLT between patients with and without ACR in the BXM group. Next, we divided the 32 patients without ACR in the BXM group into two groups: biopsied patients with abnormal SBTs and non-biopsied patients. The donor age of the biopsied patients was significantly higher than that of the non-biopsied patients. Induction with BXM reduced the incidence of ACR, and unique pathological phenomena responsible for graft dysfunction after LDLT with an increased incidence of abnormal SBTs were observed.
KW - Abnormal serum biochemical tests
KW - Acute cellular rejection
KW - Anti-IL-2R
KW - Basiliximab
KW - Donor age
KW - Living donor liver transplantation
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U2 - 10.1111/j.1399-0012.2010.01219.x
DO - 10.1111/j.1399-0012.2010.01219.x
M3 - Article
C2 - 20236134
AN - SCOPUS:79551708198
VL - 25
SP - 61
EP - 68
JO - Clinical Transplantation
JF - Clinical Transplantation
SN - 0902-0063
IS - 1
ER -