TY - JOUR
T1 - Ubiquitination-mediated autophagy against invading bacteria
AU - Fujita, Naonobu
AU - Yoshimori, Tamotsu
N1 - Funding Information:
This work was supported in part by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan (to N.F. and T.Y.) and the Takeda Science Foundation (to T.Y.).
PY - 2011/8
Y1 - 2011/8
N2 - Autophagy is primarily a non-selective intracellular bulk degradation process. However, it was recently shown that ubiquitin-positive substrates, such as protein aggregates, mitochondria, peroxisomes, and invading bacteria, are selectively targeted to lysosomes via autophagy. Thus, ubiquitination seems to function as a general tag for selective autophagy in mammalian cells. This review discusses the present model of how autophagy sequesters invading bacteria through ubiquitination.
AB - Autophagy is primarily a non-selective intracellular bulk degradation process. However, it was recently shown that ubiquitin-positive substrates, such as protein aggregates, mitochondria, peroxisomes, and invading bacteria, are selectively targeted to lysosomes via autophagy. Thus, ubiquitination seems to function as a general tag for selective autophagy in mammalian cells. This review discusses the present model of how autophagy sequesters invading bacteria through ubiquitination.
UR - http://www.scopus.com/inward/record.url?scp=79960735619&partnerID=8YFLogxK
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U2 - 10.1016/j.ceb.2011.03.003
DO - 10.1016/j.ceb.2011.03.003
M3 - Review article
C2 - 21450448
AN - SCOPUS:79960735619
VL - 23
SP - 492
EP - 497
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
IS - 4
ER -