TY - JOUR
T1 - Ubiquitination-mediated autophagy against invading bacteria
AU - Fujita, Naonobu
AU - Yoshimori, Tamotsu
PY - 2011/8
Y1 - 2011/8
N2 - Autophagy is primarily a non-selective intracellular bulk degradation process. However, it was recently shown that ubiquitin-positive substrates, such as protein aggregates, mitochondria, peroxisomes, and invading bacteria, are selectively targeted to lysosomes via autophagy. Thus, ubiquitination seems to function as a general tag for selective autophagy in mammalian cells. This review discusses the present model of how autophagy sequesters invading bacteria through ubiquitination.
AB - Autophagy is primarily a non-selective intracellular bulk degradation process. However, it was recently shown that ubiquitin-positive substrates, such as protein aggregates, mitochondria, peroxisomes, and invading bacteria, are selectively targeted to lysosomes via autophagy. Thus, ubiquitination seems to function as a general tag for selective autophagy in mammalian cells. This review discusses the present model of how autophagy sequesters invading bacteria through ubiquitination.
UR - http://www.scopus.com/inward/record.url?scp=79960735619&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960735619&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2011.03.003
DO - 10.1016/j.ceb.2011.03.003
M3 - Review article
C2 - 21450448
AN - SCOPUS:79960735619
VL - 23
SP - 492
EP - 497
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
IS - 4
ER -