Ubiquitination-mediated autophagy against invading bacteria

Naonobu Fujita, Tamotsu Yoshimori

    Research output: Contribution to journalReview article

    37 Citations (Scopus)

    Abstract

    Autophagy is primarily a non-selective intracellular bulk degradation process. However, it was recently shown that ubiquitin-positive substrates, such as protein aggregates, mitochondria, peroxisomes, and invading bacteria, are selectively targeted to lysosomes via autophagy. Thus, ubiquitination seems to function as a general tag for selective autophagy in mammalian cells. This review discusses the present model of how autophagy sequesters invading bacteria through ubiquitination.

    Original languageEnglish
    Pages (from-to)492-497
    Number of pages6
    JournalCurrent Opinion in Cell Biology
    Volume23
    Issue number4
    DOIs
    Publication statusPublished - 2011 Aug 1

    ASJC Scopus subject areas

    • Cell Biology

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