Ubiquitination-mediated autophagy against invading bacteria

Naonobu Fujita; Tamotsu Yoshimori

doi:10.1016/j.ceb.2011.03.003

Ubiquitination-mediated autophagy against invading bacteria

Naonobu Fujita, Tamotsu Yoshimori

Research output: Contribution to journal › Review article › peer-review

37 Citations (Scopus)

Abstract

Autophagy is primarily a non-selective intracellular bulk degradation process. However, it was recently shown that ubiquitin-positive substrates, such as protein aggregates, mitochondria, peroxisomes, and invading bacteria, are selectively targeted to lysosomes via autophagy. Thus, ubiquitination seems to function as a general tag for selective autophagy in mammalian cells. This review discusses the present model of how autophagy sequesters invading bacteria through ubiquitination.

Original language	English
Pages (from-to)	492-497
Number of pages	6
Journal	Current Opinion in Cell Biology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.ceb.2011.03.003
Publication status	Published - 2011 Aug

ASJC Scopus subject areas

Cell Biology

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