Two M-components in a single cell lineage in a patient with a dual isotype secretory B-cell tumour

Chizuko Sakashita, Takako Saito, Tetsuya Kurosu, Haruhiko Yoshinaga, Takasi Kumagai, Koh Yamamoto, Tohru Miki, Takatoshi Koyama, Osamu Miura, Tetsuo Nemoto, Hideo Asakawa, Shinsaku Hirosawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We describe a case of Waldenstrom's macroglobulinaemia with two M- components (IgM and IgG) with the same λ light chain. Southern blot analysis of bone marrow cells showed rearrangements of immunoglobulin heavy and λ light chain genes. Sequencing of the complementarity determining region 3 of the two γ and μ transcripts showed 100% homology. Immunofluorescence study showed that most cells stained for both IgG and IgM. These findings indicated that a single population of cells was expressing two isotypic variants of IgG and IgM, as the genes responsible for production of both components had the same origin.

Original languageEnglish
Pages (from-to)791-794
Number of pages4
JournalBritish Journal of Haematology
Volume102
Issue number3
DOIs
Publication statusPublished - 1998 Sep 1
Externally publishedYes

Keywords

  • Biclonal gammopathy
  • Clonality
  • Isotypic variants
  • Multiple myeloma
  • Waldenstrom's macroglobulinaemia

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Sakashita, C., Saito, T., Kurosu, T., Yoshinaga, H., Kumagai, T., Yamamoto, K., Miki, T., Koyama, T., Miura, O., Nemoto, T., Asakawa, H., & Hirosawa, S. (1998). Two M-components in a single cell lineage in a patient with a dual isotype secretory B-cell tumour. British Journal of Haematology, 102(3), 791-794. https://doi.org/10.1046/j.1365-2141.1998.00832.x