Two Japanese cases of anti-MOG antibody-associated encephalitis that mimicked neuro-Behçet's disease

Juichi Fujimori; Toshiyuki Takahashi; Yuki Matsumoto; K. Fujihara; Yoshiki Takai; Tatsuro Misu; Ichiro Nakashima

doi:10.1016/j.jneuroim.2019.577002

Two Japanese cases of anti-MOG antibody-associated encephalitis that mimicked neuro-Behçet's disease

Juichi Fujimori, Toshiyuki Takahashi, Yuki Matsumoto, K. Fujihara, Yoshiki Takai, Tatsuro Misu, Ichiro Nakashima

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Recently, we documented two Japanese cases of myelin-oligodendrocyte glycoprotein (MOG) antibody-associated relapsing encephalitis among patients who had been diagnosed with probable neuro-Behçet's disease (NBD). They presented partial systemic BD symptoms, brainstem lesions, and the human leukocyte antigen (HLA) B51 allele and responded well to steroid therapy. Our cases suggest that we need to differentiate anti-MOG antibody-associated encephalitis from probable NBD because both disorders can present with brainstem or cerebral lesions, CSF pleocytosis, and elevated levels of CSF IL-6 and respond to steroid treatment. Furthermore, oral ulceration, skin lesions, and HLA-B51 might be observed nonspecifically in patients with anti-MOG antibody-associated encephalitis.

Original language	English
Article number	577002
Journal	Journal of Neuroimmunology
Volume	334
DOIs	https://doi.org/10.1016/j.jneuroim.2019.577002
Publication status	Published - 2019 Sep 15

Keywords

Differential diagnosis
Encephalitis
Myelin-oligodendrocyte glycoprotein
Neuro-Behçet's disease

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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title = "Two Japanese cases of anti-MOG antibody-associated encephalitis that mimicked neuro-Beh{\c c}et's disease",

abstract = "Recently, we documented two Japanese cases of myelin-oligodendrocyte glycoprotein (MOG) antibody-associated relapsing encephalitis among patients who had been diagnosed with probable neuro-Beh{\c c}et's disease (NBD). They presented partial systemic BD symptoms, brainstem lesions, and the human leukocyte antigen (HLA) B51 allele and responded well to steroid therapy. Our cases suggest that we need to differentiate anti-MOG antibody-associated encephalitis from probable NBD because both disorders can present with brainstem or cerebral lesions, CSF pleocytosis, and elevated levels of CSF IL-6 and respond to steroid treatment. Furthermore, oral ulceration, skin lesions, and HLA-B51 might be observed nonspecifically in patients with anti-MOG antibody-associated encephalitis.",

keywords = "Differential diagnosis, Encephalitis, Myelin-oligodendrocyte glycoprotein, Neuro-Beh{\c c}et's disease",

author = "Juichi Fujimori and Toshiyuki Takahashi and Yuki Matsumoto and K. Fujihara and Yoshiki Takai and Tatsuro Misu and Ichiro Nakashima",

year = "2019",

month = sep,

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doi = "10.1016/j.jneuroim.2019.577002",

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journal = "Journal of Neuroimmunology",

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TY - JOUR

T1 - Two Japanese cases of anti-MOG antibody-associated encephalitis that mimicked neuro-Behçet's disease

AU - Fujimori, Juichi

AU - Takahashi, Toshiyuki

AU - Matsumoto, Yuki

AU - Fujihara, K.

AU - Takai, Yoshiki

AU - Misu, Tatsuro

AU - Nakashima, Ichiro

PY - 2019/9/15

Y1 - 2019/9/15

N2 - Recently, we documented two Japanese cases of myelin-oligodendrocyte glycoprotein (MOG) antibody-associated relapsing encephalitis among patients who had been diagnosed with probable neuro-Behçet's disease (NBD). They presented partial systemic BD symptoms, brainstem lesions, and the human leukocyte antigen (HLA) B51 allele and responded well to steroid therapy. Our cases suggest that we need to differentiate anti-MOG antibody-associated encephalitis from probable NBD because both disorders can present with brainstem or cerebral lesions, CSF pleocytosis, and elevated levels of CSF IL-6 and respond to steroid treatment. Furthermore, oral ulceration, skin lesions, and HLA-B51 might be observed nonspecifically in patients with anti-MOG antibody-associated encephalitis.

AB - Recently, we documented two Japanese cases of myelin-oligodendrocyte glycoprotein (MOG) antibody-associated relapsing encephalitis among patients who had been diagnosed with probable neuro-Behçet's disease (NBD). They presented partial systemic BD symptoms, brainstem lesions, and the human leukocyte antigen (HLA) B51 allele and responded well to steroid therapy. Our cases suggest that we need to differentiate anti-MOG antibody-associated encephalitis from probable NBD because both disorders can present with brainstem or cerebral lesions, CSF pleocytosis, and elevated levels of CSF IL-6 and respond to steroid treatment. Furthermore, oral ulceration, skin lesions, and HLA-B51 might be observed nonspecifically in patients with anti-MOG antibody-associated encephalitis.

KW - Differential diagnosis

KW - Encephalitis

KW - Myelin-oligodendrocyte glycoprotein

KW - Neuro-Behçet's disease

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