Two distinct mechanisms are responsible for single K channel block by internal tetraethylammonium ions

Daisuke Yamamoto, N. Suzuki

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Tetraethylammonium (TEA) ions blocked the unitary currents through the delayed rectifier potassium channels of Drosophila neurons from the cytoplasmic side of inside-out membrane patches by two distinct mechanisms. Fist, TEA attenuated the single-channel conductance, probably by producing very rapid block-unblock reactions at the inner mouth of the potassium pore. Second, TEA markedly enhanced the slow inactivation, making the incidence of channel openings highly nonrandom; blank traces with no channel openings during repetitive depolarizations showed a significant tendency to be clustered in the presence of TEA. This second action accounts for almost half of the reduction of average current produced by 10 mM internal TEA.

    Original languageEnglish
    JournalAmerican Journal of Physiology - Cell Physiology
    Volume256
    Issue number3
    Publication statusPublished - 1989 Jan 1

    ASJC Scopus subject areas

    • Physiology
    • Cell Biology

    Fingerprint Dive into the research topics of 'Two distinct mechanisms are responsible for single K channel block by internal tetraethylammonium ions'. Together they form a unique fingerprint.

    Cite this