Two-dimensional Raman correlation analysis of diseased esophagus in a rat

Sota Takanezawa, Shin Ichi Morita, Atsushi Maruyama, Takurou N. Murakami, Norimichi Kawashima, Hiroyuki Endo, Katsunori Iijima, Tohru Asakura, Tooru Shimosegawa, Hidetoshi Sato

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Abstract

Generalized two-dimensional (2D) Raman correlation analysis effectively distinguished a benign tumor from normal tissue. Line profiling Raman spectra of a rat esophagus, including a benign tumor, were measured and the generalized 2D synchronous and asynchronous spectra were calculated. In the autocorrelation area of the amide I band of proteins in the asynchronous map, a cross-like pattern was observed. A simulation study indicated that the pattern was caused by a sharp band component in the amide I band region. We considered that the benign tumor corresponded to the sharp component.

Original languageEnglish
Article number077001
JournalApplied Physics Express
Volume3
Issue number7
DOIs
Publication statusPublished - 2010 Jul 1

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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  • Cite this

    Takanezawa, S., Morita, S. I., Maruyama, A., Murakami, T. N., Kawashima, N., Endo, H., Iijima, K., Asakura, T., Shimosegawa, T., & Sato, H. (2010). Two-dimensional Raman correlation analysis of diseased esophagus in a rat. Applied Physics Express, 3(7), [077001]. https://doi.org/10.1143/APEX.3.077001