Two-dimensional nucleobase self-organization supported by base-pairing and stacking at the air-water interface

Mitsuhiko Morisue, Kuniharu Ijiro, Masatsugu Shimomura

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    Octadecyl substituted amphiphiles of the four nucleobases, adenine, cytosine, guaine, and thymine (C18-Ade, C18-Cyt, C18-Gua, and C18-Thy, respectively), were prepared. Binary mixtures of these amphiphiles were spread on water surface as monolayer assemblies. Pressure-area isotherms of all pairwise combination of the nucleobase amphiphiles indicate that the Watson-Crick type base-pairings and base-stacking can stabilize monolayers at the air-water interface. Unexpected stabilization was observed in the combination of C18-Gua and C18-Thy, which resembles a "wobble" pair in RNA. Langmuir-Blodgett films were prepared on gold substrates for FT-IR measurement of the complementary hydrogen bonding between the nucleobase amphiphiles.

    Original languageEnglish
    Pages (from-to)379-382
    Number of pages4
    JournalMolecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals
    Volume371
    DOIs
    Publication statusPublished - 2001 Jan 1

    Keywords

    • "Wobble" base-pair
    • Hydrogen bond, base-stacking
    • Molecular recognition
    • Monolayer
    • Watson-Crick type base-pair

    ASJC Scopus subject areas

    • Condensed Matter Physics

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