Two convergent routes to the left-wing fragment of ciguatoxin CTX3C using O,S-acetals as key intermediates

Masayuki Inoue, Shuji Yamashita, Yuuki Ishihara, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

(Diagram presented) Ciguatoxins, principal causative toxins of ciguatera seafood poisoning, are large ladderlike polycyclic ethers. Here, we report two convergent routes to synthesis of the multiolefinic left half of ciguatoxins based on a newly developed acyl radical strategy. Remarkably, only 13 steps from the monocyclic E-ring were required to construct the left wing.

Original languageEnglish
Pages (from-to)5805-5808
Number of pages4
JournalOrganic letters
Volume8
Issue number25
DOIs
Publication statusPublished - 2006 Dec 7

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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