Two consecutive fasciculation potentials having different motor unit origins are an electromyographically pathognomonic finding of ALS

Y. Shiga, H. Onodera, Hiroaki Shimizu, I. Kimura, A. Ohnuma, Y. Itoyama

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To electrophysiologically diagnose amyotrophic lateral sclerosis (ALS), fasciculation potentials (FPs) were evaluated in each wasted muscle in 12 ALS and 14 other neurogenic disorders (non-ALS patients). Various types of FPs were observed in ALS. The number of discharged FPs and firing rate of FPs were significantly increased in ALS compared to those in non-ALS. These findings indicate that more motor units take part in discharging FPs in ALS than in non-ALS, and that injured lower motor neurons exhibit hyperexcitability. Although nine of 12 ALS patients showed two consecutive FPs having different motor unit origins, non-ALS patients did not show such FPs. Since the two consecutive FPs having different motor unit origins reflect an involvement of both upper and lower motor neurons, these potentials are an electrophysiologically pathognomonic finding to ALS.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalElectromyography and Clinical Neurophysiology
Volume40
Issue number4
Publication statusPublished - 2000 Jun 1

Keywords

  • Amyotrophic lateral sclerosis
  • Consecutive fasciculation potentials
  • Diagnosis
  • Electromyographical finding
  • Electromyography

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Physiology (medical)

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