Abstract
We report two cases of otitis media positive for antimyeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) associated with facial palsy. Case 1: A 73-year-old man treated for 3 months for bilateral otitis media with effusion had left facial nerve palsy and deteriorated bone conduction hearing in both ears. Blood analysis showed elevated MPO-ANCA to 134 EU. Case 2: A 66-year-old woman treated for about one year for bilateral otitis media with effusion and fluctuating mixed hearing loss had bilateral facial nerve palsy and a blood test positive for MPO-ANCA at 67 EU. Both were diagnosed with otitis media caused by ANCA-related vasculitis. After prednisolone and cyclophos-phamide administration for half a year, blood test results were negative for MPO-ANCA. Both recovered almost completely from facial nerve palsy and bone conductive hearing loss partially improved except in one hearing-impaired ear. ANCA-related vasculitis of the temporal bone should thus be considered in those with intractable otitis media and deteriorated bone conduction hearing before the occurrence of facial palsy.
Original language | English |
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Pages (from-to) | 67-71 |
Number of pages | 5 |
Journal | Journal of Otolaryngology of Japan |
Volume | 113 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2010 Feb |
Externally published | Yes |
Keywords
- Anca-related vasculitis
- Facial nerve palsy
- MPO-ANCA
- Otitis media
- Progressive sensorineural hearing loss
ASJC Scopus subject areas
- Otorhinolaryngology