Two cases of MPO-ANCA-positive otitis media associated with facial palsy

Hajime Usubuchi, Kozue Kodama, Katsumi Takizawa, Takeharu Kanazawa, Yasushi Ohta, Keiko Kakizaki, Yukiko Lino

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We report two cases of otitis media positive for antimyeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) associated with facial palsy. Case 1: A 73-year-old man treated for 3 months for bilateral otitis media with effusion had left facial nerve palsy and deteriorated bone conduction hearing in both ears. Blood analysis showed elevated MPO-ANCA to 134 EU. Case 2: A 66-year-old woman treated for about one year for bilateral otitis media with effusion and fluctuating mixed hearing loss had bilateral facial nerve palsy and a blood test positive for MPO-ANCA at 67 EU. Both were diagnosed with otitis media caused by ANCA-related vasculitis. After prednisolone and cyclophos-phamide administration for half a year, blood test results were negative for MPO-ANCA. Both recovered almost completely from facial nerve palsy and bone conductive hearing loss partially improved except in one hearing-impaired ear. ANCA-related vasculitis of the temporal bone should thus be considered in those with intractable otitis media and deteriorated bone conduction hearing before the occurrence of facial palsy.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalJournal of Otolaryngology of Japan
Volume113
Issue number2
DOIs
Publication statusPublished - 2010 Feb
Externally publishedYes

Keywords

  • Anca-related vasculitis
  • Facial nerve palsy
  • MPO-ANCA
  • Otitis media
  • Progressive sensorineural hearing loss

ASJC Scopus subject areas

  • Otorhinolaryngology

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