Two cases of interstitial lung diseases in patients treated with oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX)

Hisatsugu Ohori, Masanobu Takahashi, Nobutaka Ogasawara, Michihiro Suzuki, Yoshiharu Miyate, Satoshi Kato

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Oxaliplatin in combination with 5-fluorouracil (5-FU) and Leucovorin (FOLFOX) currently represents a valid approach for treating advanced colorectal cancer. In Japan, it is generally performed. Gastrointestinal, hematological and neurosensory toxicities are the most common. However, information concerning the pulmonary toxicity of this regimen is very limited. We report here two cases of interstitial lung disease occurring in association with the use of this combination chemotherapy. Reports of interstitial lung disease due to FOLFOX are infrequent, but could lead to severe complications. It is important to perform an X-ray examination regularly and detect symptoms early.

Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume36
Issue number2
Publication statusPublished - 2009 Jan 1

Keywords

  • FOLFOX
  • Interstitial lung disease
  • Oxaliplatin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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