Two cases of advanced gastric cancer achieved pathological complete response by preoperative chemotherapy with S-1 plus Weekly Low-Dose CDDP

Emiko Kono, Naoki Tanaka, Katsuyosi Kudo, Hiroaki Musha, Takahiro Tsuchiya, Tomohiro Miyachi, Munenori Nagao, Taiki Kajiwara, Shunichi Kimura, Hideaki Karasawa, Takeshi Aoki, Tomoya Abe, Shinobu Ohnuma, Kei Nakagawa, Takanori Morikawa, Hiroshi Yoshida, Fuyuhiko Motoi, Yu Katayose, Takeshi Naito, Michiaki Unno

Research output: Contribution to journalArticlepeer-review

Abstract

We report 2 cases of resectable advanced gastric cancer who achieved pathological complete response by preoperative chemotherapy with S-1 plus weekly low-dose cisplatin (CDDP). S-1 (80 mg/m2) was administered consecutively for 21 days followed by 14 days' rest, with CDDP (25 mg/m2) injected on days 1, 8, and 21. Case 1: A man in his 70s diagnosed with cStage III gastric cancer with lymph node metastases received 2 courses of preoperative chemotherapy with S-1 plus weekly low-dose CDDP followed by total gastrectomy with D2 lymph node dissection. Case 2: A man in his 60s diagnosed with cStage III gastric cancer with lymph node metastases received 4 courses of preoperative chemotherapy with S-1 plus weekly low-dose CDDP followed by total gastrectomy with D2 lymph-node dissection. In both cases, postoperative pathological examination revealed no cancer cells in the resected stomach and lymph nodes. The therapeutic effect of preoperative chemotherapy was assessed as Grade 3. With this regimen, we accomplished preoperative chemotherapy successfully without inpatient care. This regimen can be a promising option as preoperative chemotherapy for advanced gastric cancer.

Original languageEnglish
Pages (from-to)2279-2281
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Volume41
Issue number12
Publication statusPublished - 2014 Nov

Keywords

  • Gastric cancer
  • Pathological complete response
  • Preoperative chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Two cases of advanced gastric cancer achieved pathological complete response by preoperative chemotherapy with S-1 plus Weekly Low-Dose CDDP'. Together they form a unique fingerprint.

Cite this