TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage

Yuki Kaduka, Kazuyoshi Takeda, Masafumi Nakayama, Katsuyuki Kinoshita, Hideo Yagita, Ko Okumura

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20 Citations (Scopus)

Abstract

TWEAK induces diverse cellular responses, including pro-inflammatory chemokine production, migration, proliferation, and cell death through the TWEAK receptor, Fn14. In the present study, we examined the effect of TWEAK or Fn14 expression in tumor cells on tumor outgrowth in vivo. Administration of neutralizing anti-TWEAK mAb significantly reduced the frequency of tumor rejection and shortened the survival of mice intraperitoneally inoculated with TWEAK-sensitive Fn14-expressing tumor cells. Moreover, anti-TWEAK mAb treatment promoted the subcutaneous growth of TWEAK-sensitive Fn14-expressing tumor cells, and this promotion was abolished by the inhibition of macrophage infiltration but not NK cell depletion. In contrast, administration of anti-TWEAK mAb had no apparent effect on the growth of TWEAK-resistant tumor cells, even if tumor cells expressed Fn14. On the other hand, TWEAK expression in tumor cells had no significant effect on subcutaneous tumor growth. These results indicate that TWEAK mediates anti-tumor effect of macrophages in vivo.

Original languageEnglish
Pages (from-to)384-390
Number of pages7
JournalBiochemical and biophysical research communications
Volume331
Issue number2
DOIs
Publication statusPublished - 2005 Jun 3

Keywords

  • Apoptosis
  • Fn14
  • Macrophage
  • TWEAK
  • Tumor

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Kaduka, Y., Takeda, K., Nakayama, M., Kinoshita, K., Yagita, H., & Okumura, K. (2005). TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage. Biochemical and biophysical research communications, 331(2), 384-390. https://doi.org/10.1016/j.bbrc.2005.03.176