Tumor uptake of [48V]Vanadyl-chlorine e6Na as a tumor-imaging agent in tumor-bearing mice

Kuni Iwai, Shuichi Kimura, Tatsuo Ido, Ren Iwata

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    9 Citations (Scopus)

    Abstract

    [48V]Vanadyl-chlorine e6Na (48V-Chl) which was synthesized by insertion of 48V (positron emitter) into chlorine e6Na (Chl), a chlorophyll derivative having a similar structure to pheophorbide-a (Pheo), localized rapidly in experimental mammary carcinoma. The tumor-to-organ ratios of 48V-Chl were higher than those of 48V-labeled Pheo (48V-Pheo), and 48V-Chl showed a clear tumor image with low accumulation in liver, depending on the biodistribution of metal-free Chl having an affinity with tumor. 48V-Chl seems to be more suitable than 48V-Pheo as a tumor-imaging agent for photodynamic therapy of tumors.

    Original languageEnglish
    Pages (from-to)775-777,779-780
    JournalInternational Journal of Radiation Applications and Instrumentation.
    Volume17
    Issue number8
    DOIs
    Publication statusPublished - 1990

    ASJC Scopus subject areas

    • Medicine(all)

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