Tumor image extraction from fluoroscopy for a markerless lung tumor motion tracking and prediction

Noriyasu Homma, Keita Ishihara, Yoshihiro Takai, Haruna Endo, Kei Ichiji, Masao Sakai, Yuichiro Narita, Makoto Abe, Norihiro Sugita, Makoto Yoshizawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We develop a markerless tumor motion tracking technique for accurate and safer image-guided radiation therapy (IGRT). The technique is implemented based on a new image model of the moving tumor and the background structure in an x-ray fluorocopic image sequence. By using the technique, the moving tumor image can be extracted from the sequential fluoroscopic images. The extraction from the fluoroscopy is obviously ill- posed, but we have suggested that it can be regularized into a well-posed problem by temporally accumulating constraints that must be satisfied by the extracted tumor image and the background. In this paper, the effect of the tumor extraction and motion of both the tumor and background in the image model is extensively studied on the tracking accuracy. The tracking accuracy of the proposed method with extraction of both the moving tumor and background was within $0.2$ mm of the spatial resolution for a phantom dataset. The accuracy within 1 mm can be clinically sufficient and is superior to the results by the previous method with extraction model of only the moving tumor and by a conventional method without extraction. Thus, the results clearly demonstrate the efficiency and usefulness of the proposed extraction model for the IGRT.

Original languageEnglish
Title of host publicationMedical Imaging 2012
Subtitle of host publicationImage-Guided Procedures, Robotic Interventions, and Modeling
Publication statusPublished - 2012
EventMedical Imaging 2012: Image-Guided Procedures, Robotic Interventions, and Modeling - San Diego, CA, United States
Duration: 2012 Feb 52012 Feb 7

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2012: Image-Guided Procedures, Robotic Interventions, and Modeling
Country/TerritoryUnited States
CitySan Diego, CA


  • accurate radiation therapy
  • image-guided technique
  • implanted marker risk
  • lung tumor
  • markerless real-time tumor tracking
  • respiratory motion

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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