Tumor doubling time and prognostic assessment of patients with primary lung cancer

Katsuo Usuda, Yasuki Saito, Motoyasu Sagawa, Masami Sato, Keiji Kanma, Satomi Takahashi, Chiaki Endo, Yan Chen, Akira Sakurada, Shigefumi Fujimura

Research output: Contribution to journalArticlepeer-review

185 Citations (Scopus)


Background. Relationships between tumor doubling time (DT) and other prognostic factors and the risk of death related to these factors are not yet fully understood. Methods. Tumor doubling time of primary lung carcinomas of 174 patients, detected in a limited number of local municipalities during a limited period, was calculated using the Schwartz formula. Survival rate of the 174 patients was compared with reference to categories of prognostic factors (univariate analyses) and significant factors affecting survival were identified by multivariate analyses using the Cox proportional hazard model. Results. Tumor doubling time had a log normal distribution. There was a significant difference in mean DT in relation to sex, smoking history, presence of symptoms, cell type, primary tumor factor, and stage. Univariate analyses showed a significant difference in survival in relation to DT, age, sex, method of tumor detection, smoking history, symptoms, therapy, cell type, primary tumor (T) factor, regional lymph node (N) factor, distant metastasis (M) factor, and stage. Multivariate analyses using the Cox's proportional hazard model in a stepwise fashion identified a final set of five significant variables: N factor (P = 0.0001); therapy (P = 0.0016); M factor (P = 0.0017); T factor (P = 0.0018), and DT (P = 0.0152). Conclusions. Tumor doubling time was an independent and significant prognostic factor for lung cancer patients.

Original languageEnglish
Pages (from-to)2239-2244
Number of pages6
Issue number8
Publication statusPublished - 1994 Oct 15


  • Cox proportional hazard model
  • growth rate
  • multivariate analysis
  • primary lung cancer
  • prognostic factor
  • survival rate
  • tumor doubling time

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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