Tumor-associated macrophages correlate with vascular space invasion and myometrial invasion in endometrial carcinoma

Shu Soeda, Naoya Nakamura, Takeharu Ozeki, Hiroshi Nishiyama, Hiroshi Hojo, Hidekazu Yamada, Masafumi Abe, Akira Sato

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    54 Citations (Scopus)

    Abstract

    Objective: This study was conducted to determine whether tumor-associated macrophages (TAMs) correlate with clinicopathological features in endometrioid adenocarcinoma. Methods: 76 cases of endometrioid adenocarcinoma treated initially by hysterectomy with pelvic lymphadenectomy were retrospectively retrieved, and their histological features were evaluated. Immunohistochemical staining for CD68, CD34, and Ki-67 was performed on paraffin-embedded sections. TAMs were counted in two areas: in the invasive margin (margin TAMs) and in the tumor (intratumor TAMs). Results: Margin TAMs were significantly associated with FIGO stage (P = 0.033), histological grade (P = 0.008), myometrial invasion (P = 0.0001), pelvic lymph node metastasis (P = 0.027), and vascular space invasion (P = 0.0001). Intratumor TAMs were significantly associated with intratumor Ki-67 (P = 0.006) and microvessel density (P = 0.020). Patients with high margin TAMs (≥ 20) had significantly worse progression-free survival (PS) and overall survival (OS) than those with low margin TAMs (< 20) (log rank test, P = 0.0031 and P = 0.0085, respectively). On multivariate analysis, high margin TAMs were significantly associated with vascular space invasion (P = 0.013; HR, 6.05; 95% confidence interval [CI], 1.468-24.938) and myometrial invasion (P = 0.041; HR, 4.03; 95% CI, 1.06-14.71). Vascular space invasion was only associated with PFS. Conclusion: Although on univariate analysis TAMs are associated with other poor prognosticators, on a multivariate analysis, TAMs appear only to be associated with MI and VI. TAMs may play a significant role in the biology of tumor progression of endometrial adenocarcinoma, but do not appear to be independent prognostic indicators of patient's survival.

    Original languageEnglish
    Pages (from-to)122-128
    Number of pages7
    JournalGynecologic Oncology
    Volume109
    Issue number1
    DOIs
    Publication statusPublished - 2008 Apr 1

    Keywords

    • CD68
    • Endometrioid adenocarcinoma
    • Immunohistochemistry
    • Survival
    • Tumor-associated macrophages
    • Vascular space invasion

    ASJC Scopus subject areas

    • Oncology
    • Obstetrics and Gynaecology

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  • Cite this

    Soeda, S., Nakamura, N., Ozeki, T., Nishiyama, H., Hojo, H., Yamada, H., Abe, M., & Sato, A. (2008). Tumor-associated macrophages correlate with vascular space invasion and myometrial invasion in endometrial carcinoma. Gynecologic Oncology, 109(1), 122-128. https://doi.org/10.1016/j.ygyno.2007.12.033