Tuberculosis screening programme using the QuantiFERON®-TB Gold test and chest computed tomography for healthcare workers accidentally exposed to patients with tuberculosis

T. Hirama, K. Hagiwara, M. Kanazawa

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Healthcare workers (HCWs) have an increased incidence of tuberculosis (TB). Periodic and as-needed screenings of HCWs exposed to patients with TB are important. We integrated chest computed tomography (CT) and the QuantiFERON ®-TB Gold (QFT-G) test into our TB screening programme for HCWs. First, contacts were tested using the QFT-G test. Those positive for the QFT-G test were investigated by CT and classified as having active, latent (LTBI), or old TB. Between April 2005 and April 2010, 11 patients who had not been diagnosed with active TB on admission were found to have the disease. A total of 512 close or high risk contacts were identified, and underwent screening. Out of those, 34 (6.64%) were QFT-G positive, whereas 478 (93.36%) were negative. Of the 34 QFT-G-positive HCWs, four had CT findings compatible with active TB and received multidrug treatment; 24 showed no findings of active TB and received isoniazid for six months. All completed their regimens without any adverse effects. The TB screening programme integrating CT and the QFT-G test was safe and feasible. The efficacy of the programme needs to be confirmed by large scale clinical trials.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalJournal of Hospital Infection
Volume77
Issue number3
DOIs
Publication statusPublished - 2011 Mar
Externally publishedYes

Keywords

  • Chest computed tomography
  • Healthcare workers
  • QuantiFERON®-TB Gold test

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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