TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity

Takahiro Shiba, Takashi Maruyama, Kohta Kurohane, Yusaku Iwasaki, Tatsuo Watanabe, Yasuyuki Imai

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    We have revealed that local stimulation of sensory neurons is involved in the adjuvant effect of dibutyl phthalate (DBP) in a fluorescein isothiocyanate-induced mouse contact hypersensitivity model. Transient receptor potential (TRP) A1 and TRPV1 seemed to be candidate DBP targets. Here we directly demonstrated that DBP activates a subset of neurons in mouse dorsal root ganglia responsive to TRPA1 and TRPV1 agonists. TRPA1 and TRPV1 activation was further demonstrated using cultured cells expressing TRP channels. Among structurally different phthalate esters, there is a positive relationship between the activation of TRPA1- or TRPV1-expressing cells and the adjuvant effect.

    Original languageEnglish
    Pages (from-to)66-74
    Number of pages9
    JournalJournal of Neuroimmunology
    Volume207
    Issue number1-2
    DOIs
    Publication statusPublished - 2009 Feb 15

    Keywords

    • Allergy
    • Skin
    • TRPA1
    • TRPV1

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Neurology
    • Clinical Neurology

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