Tropone skeleton enhances the dispersion stability of nano-prodrugs

Keita Tanita; Yoshitaka Koseki; Takaaki Kamishima; Hitoshi Kasai

doi:10.1246/cl.190876

Tropone skeleton enhances the dispersion stability of nano-prodrugs

Keita Tanita, Yoshitaka Koseki, Takaaki Kamishima, Hitoshi Kasai

Polymer Hybrid Materials Research Center

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We synthesized hinokitiol-modified SN-38 prodrugs and fabricated their nano-prodrugs which are nanoparticles composed of only prodrug molecules by the reprecipitation method. These nano-prodrugs possessed high dispersion stability, and further research revealed that the tropone skeleton of hinokitiol is the key structure for the dispersion stability in our prodrug design. In addition, the nanoparticles of hinokitiol-modified SN-38 showed much higher cytotoxicity against cancer cells than irinotecan, the pharmaceutically available prodrug of SN-38.

Original language	English
Pages (from-to)	222-224
Number of pages	3
Journal	Chemistry Letters
Volume	49
Issue number	3
DOIs	https://doi.org/10.1246/cl.190876
Publication status	Published - 2020

Keywords

Drug delivery system
Reprecipitation method
Tropone skeleton

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.190876

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title = "Tropone skeleton enhances the dispersion stability of nano-prodrugs",

abstract = "We synthesized hinokitiol-modified SN-38 prodrugs and fabricated their nano-prodrugs which are nanoparticles composed of only prodrug molecules by the reprecipitation method. These nano-prodrugs possessed high dispersion stability, and further research revealed that the tropone skeleton of hinokitiol is the key structure for the dispersion stability in our prodrug design. In addition, the nanoparticles of hinokitiol-modified SN-38 showed much higher cytotoxicity against cancer cells than irinotecan, the pharmaceutically available prodrug of SN-38.",

keywords = "Drug delivery system, Reprecipitation method, Tropone skeleton",

author = "Keita Tanita and Yoshitaka Koseki and Takaaki Kamishima and Hitoshi Kasai",

note = "Funding Information: We would like to thank Dr. Hiroshi Yabu of IMRAM, Tohoku University, who established the in vitro experiment. This study was supported by JSPS Grants-in-Aid for Scientific Research (No. 19K15690, and No. 19H02785), the Cooperative Research Program of “Network Joint Research Center for Materials and Devices”, and the Research Program of “Dynamic Alliance for Open Innovation Bridging Human, Environment and Materials” in “Network Joint Research Center for Materials and Devices”.",

year = "2020",

doi = "10.1246/cl.190876",

language = "English",

volume = "49",

pages = "222--224",

journal = "Chemistry Letters",

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publisher = "Chemical Society of Japan",

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T1 - Tropone skeleton enhances the dispersion stability of nano-prodrugs

AU - Tanita, Keita

AU - Koseki, Yoshitaka

AU - Kamishima, Takaaki

AU - Kasai, Hitoshi

N1 - Funding Information: We would like to thank Dr. Hiroshi Yabu of IMRAM, Tohoku University, who established the in vitro experiment. This study was supported by JSPS Grants-in-Aid for Scientific Research (No. 19K15690, and No. 19H02785), the Cooperative Research Program of “Network Joint Research Center for Materials and Devices”, and the Research Program of “Dynamic Alliance for Open Innovation Bridging Human, Environment and Materials” in “Network Joint Research Center for Materials and Devices”.

PY - 2020

Y1 - 2020

N2 - We synthesized hinokitiol-modified SN-38 prodrugs and fabricated their nano-prodrugs which are nanoparticles composed of only prodrug molecules by the reprecipitation method. These nano-prodrugs possessed high dispersion stability, and further research revealed that the tropone skeleton of hinokitiol is the key structure for the dispersion stability in our prodrug design. In addition, the nanoparticles of hinokitiol-modified SN-38 showed much higher cytotoxicity against cancer cells than irinotecan, the pharmaceutically available prodrug of SN-38.

AB - We synthesized hinokitiol-modified SN-38 prodrugs and fabricated their nano-prodrugs which are nanoparticles composed of only prodrug molecules by the reprecipitation method. These nano-prodrugs possessed high dispersion stability, and further research revealed that the tropone skeleton of hinokitiol is the key structure for the dispersion stability in our prodrug design. In addition, the nanoparticles of hinokitiol-modified SN-38 showed much higher cytotoxicity against cancer cells than irinotecan, the pharmaceutically available prodrug of SN-38.

KW - Drug delivery system

KW - Reprecipitation method

KW - Tropone skeleton

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