Tropone skeleton enhances the dispersion stability of nano-prodrugs

Keita Tanita, Yoshitaka Koseki, Takaaki Kamishima, Hitoshi Kasai

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We synthesized hinokitiol-modified SN-38 prodrugs and fabricated their nano-prodrugs which are nanoparticles composed of only prodrug molecules by the reprecipitation method. These nano-prodrugs possessed high dispersion stability, and further research revealed that the tropone skeleton of hinokitiol is the key structure for the dispersion stability in our prodrug design. In addition, the nanoparticles of hinokitiol-modified SN-38 showed much higher cytotoxicity against cancer cells than irinotecan, the pharmaceutically available prodrug of SN-38.

Original languageEnglish
Pages (from-to)222-224
Number of pages3
JournalChemistry Letters
Volume49
Issue number3
DOIs
Publication statusPublished - 2020

Keywords

  • Drug delivery system
  • Reprecipitation method
  • Tropone skeleton

ASJC Scopus subject areas

  • Chemistry(all)

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