Trophic effect of glicentin on intestinal mucosa during administration of elemental diet in rats

H. Naito, I. Sasaki, M. Takahashi, C. Shibata, T. Doi, N. Ohtani, K. Koyama, S. Matsuno, A. Ohneda, T. Nagasaki, K. Sasaki

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1 Citation (Scopus)


This experimental study was designed to elucidate whether glicentin 1-69 which has been newly synthesized has the trophic effect on the intestinal mucosa or not. Fourteen male SD rats weighing about 150g were used and divided into two groups : 8 rats in control group (C-group), and 6 rats in glicentin group (G-group). For seven days, all rats were fed by elemental diet solution (1 kcal/ml, Elental®, Morishita, Japan) without giving normal chows or ordinary drinking water to produce the mucosal atrophy of small intestine. During this period, these rats received 0.5 mL subcutaneous injections of either saline (C-group) or glicentin (10 μg/body: G-group) every 12 hours. All injections were mixed with 0.5 ml of 16% hydrolyzed gelatin. On the eighth day, all rats were sacrificed and measured body weight, weight of scraped mucosa and villous height of jejunum and ileum and plasma total-GLI levels. Body weight of G-group did not differ significantly from C-group. Jejunal mucosal weight was significantly greater than C-group. Ileal mucosal weight of C-group was similar to G-group. The villous heights in the proximal and middle intestine of G-group were significantly higher than C-group, while there was no significant differences between G-and C-group in distal intestine. The plasma total-GLI levels of G-group were about two times higher than C-group. These results suggest that glicentin is trophic for proximal intestinal mucosa.

Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalBiomedical Research
Issue numberSUPPL. 2
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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