TY - JOUR
T1 - tRNA recycling on stalled ribosomes
AU - Inada, Toshifumi
N1 - Funding Information:
Research in the author’s laboratory is funded by Austrian Science Fund (FWF) grant P27024-BBL to A.L.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - In the ribosome-associated quality control (RQC) pathway, stalled ribosomes are ubiquitinated and dissociated into subunits. The nascent protein chain associated with the 60S ribosomal subunit is ubiquitinated by the E3 ligase Listerin (Ltn1) and is released from tRNA by ANKZF1 (Vms1) for proteasomal degradation. Shao and colleagues now report that ANKZF1 (Vms1)-cleaved tRNAs are recycled via a two-step process that requires the removal of a terminal 2′,3′-cyclic phosphate and the addition of CCA by TRNT1.
AB - In the ribosome-associated quality control (RQC) pathway, stalled ribosomes are ubiquitinated and dissociated into subunits. The nascent protein chain associated with the 60S ribosomal subunit is ubiquitinated by the E3 ligase Listerin (Ltn1) and is released from tRNA by ANKZF1 (Vms1) for proteasomal degradation. Shao and colleagues now report that ANKZF1 (Vms1)-cleaved tRNAs are recycled via a two-step process that requires the removal of a terminal 2′,3′-cyclic phosphate and the addition of CCA by TRNT1.
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U2 - 10.1038/s41594-019-0222-1
DO - 10.1038/s41594-019-0222-1
M3 - Article
C2 - 31011210
AN - SCOPUS:85064764437
VL - 26
SP - 340
EP - 342
JO - Nature Structural Biology
JF - Nature Structural Biology
SN - 1545-9993
IS - 5
ER -