tRNA recycling on stalled ribosomes

Research output: Contribution to journalArticle

Abstract

In the ribosome-associated quality control (RQC) pathway, stalled ribosomes are ubiquitinated and dissociated into subunits. The nascent protein chain associated with the 60S ribosomal subunit is ubiquitinated by the E3 ligase Listerin (Ltn1) and is released from tRNA by ANKZF1 (Vms1) for proteasomal degradation. Shao and colleagues now report that ANKZF1 (Vms1)-cleaved tRNAs are recycled via a two-step process that requires the removal of a terminal 2′,3′-cyclic phosphate and the addition of CCA by TRNT1.

Original languageEnglish
Pages (from-to)340-342
Number of pages3
JournalNature Structural and Molecular Biology
Volume26
Issue number5
DOIs
Publication statusPublished - 2019 May 1

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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