tRNA recycling on stalled ribosomes

Toshifumi Inada

doi:10.1038/s41594-019-0222-1

tRNA recycling on stalled ribosomes

Toshifumi Inada

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article

Abstract

In the ribosome-associated quality control (RQC) pathway, stalled ribosomes are ubiquitinated and dissociated into subunits. The nascent protein chain associated with the 60S ribosomal subunit is ubiquitinated by the E3 ligase Listerin (Ltn1) and is released from tRNA by ANKZF1 (Vms1) for proteasomal degradation. Shao and colleagues now report that ANKZF1 (Vms1)-cleaved tRNAs are recycled via a two-step process that requires the removal of a terminal 2′,3′-cyclic phosphate and the addition of CCA by TRNT1.

Original language	English
Pages (from-to)	340-342
Number of pages	3
Journal	Nature Structural and Molecular Biology
Volume	26
Issue number	5
DOIs	https://doi.org/10.1038/s41594-019-0222-1
Publication status	Published - 2019 May 1

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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Inada, T. (2019). tRNA recycling on stalled ribosomes. Nature Structural and Molecular Biology, 26(5), 340-342. https://doi.org/10.1038/s41594-019-0222-1

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