Trimethine cyanine dyes as deep-red fluorescent indicators with high selectivity to the internal loop of the bacterial A-site RNA

Yusuke Sato, Sayaka Yajima, Akifumi Taguchi, Kyosuke Baba, Mayu Nakagomi, Yuri Aiba, Seiichi Nishizawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We report that TO-PRO-3, a thiazole orange analogue with a trimethine bridge, functions as a deep-red fluorescent indicator for the internal loop structure of the bacterial (Escherichia coli) ribosomal decoding region of the aminoacyl-tRNA site (A-site), which enables the assessment of A-site binding capability of various test compounds including blue and even-green-emitting compounds.

Original languageEnglish
Pages (from-to)3183-3186
Number of pages4
JournalChemical Communications
Volume55
Issue number22
DOIs
Publication statusPublished - 2019

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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