Triflic acid-catalyzed cascade cyclization of arenyl enynes via acetylene-cation cyclization and Friedel-Crafts type reaction

Tienan Jin, Junichi Uchiyama, Masafumi Himuro, Yoshinori Yamamoto

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

A novel triflic acid-catalyzed cascade cyclization of arenyl 1,7-enynes through acetylene-cation cyclization followed by Friedel-Crafts reaction has been described. Various fused poly carbocycles can be obtained in good to high yields under mild reaction conditions.

Original languageEnglish
Pages (from-to)2069-2071
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number17
DOIs
Publication statusPublished - 2011 Apr 27

Keywords

  • Acetylene-cation cyclization
  • Arenyl enynes
  • Friedel-Crafts type reaction
  • Fused carbocycles
  • Triflic acid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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