Triazole-linked analogue of deoxyribonucleic acid (TLDNA): Design, synthesis, and double-strand formation with natural DNA

Hiroyuki Isobe; Tomoko Fujino; Naomi Yamazaki; Marine Guillot-Nieckowski; Eiichi Nakamura

doi:10.1021/ol801230k

Triazole-linked analogue of deoxyribonucleic acid (^TLDNA): Design, synthesis, and double-strand formation with natural DNA

Hiroyuki Isobe, Tomoko Fujino, Naomi Yamazaki, Marine Guillot-Nieckowski, Eiichi Nakamura

Research output: Contribution to journal › Article › peer-review

143 Citations (Scopus)

Abstract

(Chemical Equation Presented) A new triazole-linked analogue of DNA ( ^TLDNA) has been designed and synthesized using click chemistry. The chain elongation reaction using copper-catalyzed Huisgen cycloaddition was successful and gave the artificial oligonucleotide that formed a stable double strand with the complementary strand of natural DNA.

Original language	English
Pages (from-to)	3729-3732
Number of pages	4
Journal	Organic letters
Volume	10
Issue number	17
DOIs	https://doi.org/10.1021/ol801230k
Publication status	Published - 2008 Dec 1

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol801230k

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abstract = "(Chemical Equation Presented) A new triazole-linked analogue of DNA ( TLDNA) has been designed and synthesized using click chemistry. The chain elongation reaction using copper-catalyzed Huisgen cycloaddition was successful and gave the artificial oligonucleotide that formed a stable double strand with the complementary strand of natural DNA.",

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AU - Nakamura, Eiichi

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