Trends of genetic relationship of serotype 23F penicillin-resistant streptococcus pneumoniae in Japan

Ryoji Yoshida, Yoichi Hirakata, Mitsuo Kaku, Hiromu Takemura, Hironori Tanaka, Kazunori Tomono, Hironobu Koga, Shigeru Kohno, Shimeru Kamihira

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

No data on the genetic analysis of penicillin-resistant Streptococcus pneumoniae (PRP) in Japan has been reported. The Smal restriction endonuclease digested patterns of chromosomal DNAs from 15 PRP serotyped 23F isolated in Japan were analyzed by pulsed-field gel electrophoresis (PFGE). The isolates were genetically heterogeneous and seven different PFGE patterns were identified. Nine strains were also resistant to erythromycin and tetracycline. Four strains revealed resistance to ceftriaxone. The PFGE patterns of some strains isolated in Nagasaki University Hospital were identical to each other and closely resembled those of isolates from three different areas of Japan. These results indicate a need for additional studies by PFGE to determine the possibility of clonal spread in Japan.

Original languageEnglish
Pages (from-to)232-238
Number of pages7
JournalChemotherapy
Volume43
Issue number4
DOIs
Publication statusPublished - 1997 Jan 1
Externally publishedYes

Keywords

  • Ceftriaxone resistant
  • Erythromycin resistant
  • Penicillin-resistant
  • Pulsed-field gel electrophoresis
  • Streptococcus pneumoniae
  • Tetracycline resistant

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

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