Trends in periodontal regeneration therapy: Potential therapeutic strategy of extracellular matrix administration for periodontal ligament regeneration

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Current strategy for the treatment of periodontal disease is to application of stem cells or functional molecules that can reorganize tissue integrity, cellular activities and extracellular matrix framework to recover peridontal tissue function. The approach to be regeneration of periodontal ligament (PDL) that is a tooth supporting connective tissue has made a progress for consideration of strategies in regeneration therapy of periodontal tissue damaged by periodontitis. To realize the achieving functional PDL regeneration, the application of stem cells and functional molecules which are essential for PDL regeneration/development must be developed. The identification of stem cells/progenitors and functional molecules that contribute PDL regeneration will substantial contribution for realization of the regeneration therapy as a novel treatment of connective tissue disease. This review describes current strategy of functional PDL regeneration based on development, stem cell biology and tissue engineering after pathological degradation by periodontitis. The present status of the hurdles to this technology are also described and discussed.

Original languageEnglish
Title of host publicationInterface Oral Health Science 2014
Subtitle of host publicationInnovative Research on Biosis-Abiosis Intelligent Interface
PublisherSpringer Japan
Pages169-180
Number of pages12
ISBN (Electronic)9784431551928
ISBN (Print)9784431551256
DOIs
Publication statusPublished - 2015 Jan 1

Keywords

  • Extracellular matrix
  • Marfan syndrome
  • Microfibril
  • Periodontal ligament
  • Regeneration therapy

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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