Trends in adjuvant therapy after breast-conserving surgery for ductal carcinoma in situ of breast: a retrospective cohort study using the National Breast Cancer Registry of Japan

Daisuke Yotsumoto, Yasuaki Sagara, Hiraku Kumamaru, Naoki Niikura, Hiroaki Miyata, Chizuko Kanbayashi, Hitoshi Tsuda, Yutaka Yamamoto, Kenjiro Aogi, Makoto Kubo, Kenji Tamura, Naoki Hayashi, Minoru Miyashita, Takayuki Kadoya, Shigehira Saji, Masakazu Toi, Shigeru Imoto, Hiromitsu Jinno

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Radiotherapy (RT) and endocrine therapy (ET) are standard treatment options after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS). We investigated the national patterns of adjuvant therapy use after BCS for DCIS in Japan. Methods: We obtained relevant data of patients diagnosed with DCIS undergoing surgery and treated with BCS between 2014 and 2016 from the Japanese Breast Cancer Registry database. The relationship between the clinicopathologic, institutional, and regional factors, and adjuvant treatment was examined using multivariable analyses. Results: We identified 9516 patients who underwent BCS for DCIS. Overall, 23% received no adjuvant treatment, 71% received RT, 32% received ET, and 26% received combination therapy. The percentages of patients who received ET and combination therapy in 2016 were significantly lower [odds ratio (OR): 0.71, 0.77, respectively] than in 2014. The proportion of RT was low among young or elderly patients (OR: 0.75, 0.44, respectively) and in non-certified facilities (OR: 0.56). The proportion of ET was high in non-certified facilities (OR: 1.58) and among patients with positive margins (OR: 1.62). Combination therapy was higher among patients with positive margins (OR: 1.53). Conclusions: Our study found a distinct adjuvant treatment pattern after BCS for DCIS depending on clinicopathologic factors, year, age, which indicate that physicians provide individualized treatment according to the background of the patients and the biology of DCIS. The facilities and regions remain significant factors of influencing adjuvant treatment pattern.

Original languageEnglish
JournalBreast Cancer
DOIs
Publication statusAccepted/In press - 2021
Externally publishedYes

Keywords

  • Adjuvant therapy
  • Ductal carcinoma in situ
  • Endocrine therapy
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

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