Trends in acute myocardial infarction incidence and mortality over 30 years in Japan: Report from the MIYAGI-AMI registry study

Toru Takii, Satoshi Yasuda, Jun Takahashi, Kenta Ito, Nobuyuki Shiba, Kunio Shirato, Hiroaki Shimokawa

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Background: Worldwide, the rate of aging is highest in Japan, especially the female population. To explore the trends for acute myocardial infarction (AMI) in Japan, the MIYAGI-AMI Registry Study has been conducted for 30 years since 1979, whereby all AMI patients in the Miyagi prefecture are prospectively registered. Methods and Results: In 1979-2008, 22,551 AMI patients (male/female 16,238/6,313) were registered from 43 hospitals. The age-adjusted incidence of AMI (/100,000 persons/year) increased from 7.4 in 1979 to 27.0 in 2008 (P<0.001). Although control of coronary risk factors remained insufficient, the rates of ambulance use and primary percutaneous coronary intervention (PCI) have increased, and the overall in-hospital mortality (ageadjusted) has decreased from 20.0% in 1979 to 7.8% in 2008 (P<0.0001). However, the in-hospital mortality remains relatively higher in female than in male patients (12.2% vs 6.3% in 2008). Female patients were characterized by higher age and lower PCI rate. Conclusions: The MIYAGI-AMI Registry Study demonstrates the steady trend of an increasing incidence, but decreasing mortality, for AMI in Japan over the past 30 years, although the female population still remains at higher risk for in-hospital death, despite improvements in the use of ambulances and primary PCI.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalCirculation Journal
Volume74
Issue number1
DOIs
Publication statusPublished - 2010 Jan

Keywords

  • Acute myocardial infarction
  • Aging
  • Gender
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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