Trend of westernization of etiology and clinical characteristics of heart failure patients in Japan: First report from the CHART-2 Study

Nobuyuki Shiba, Kotaro Nochioka, Masanobu Miura, Haruka Kohno, Hiroaki Shimokawa

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Background: Hospitalization due to acute heart failure syndrome (AHFS) is an indicator of worsened prognosis for patients with cardiovascular disease (CVD). The Chronic Heart Failure Analysis and Registry in the Tohoku District 2 (CHART-2) Study was designed to elucidate characteristics and prognosis of patients at high risk for CVD progression due to AHFS. Methods and Results: The CHART-2 Study is a prospective observational multicenter cohort study. Patients with overt HF, structural cardiac disorder but without HF, or with coronary artery disease (CAD) have been consecutively enrolled from October 2006. As of March 2010, a total of 10,219 patients have been recruited, making the Study the largest multicenter prospective cohort of HF patients in Japan. The mean patient age was 68.2±12.3 years and male patients accounted for 69.8%. Overt HF was observed in 46.3% of patients; and 53.7% did not have HF but were at high risk for AHFS. As HF stage progressed, the prognostic risks (eg, chronic kidney disease, reduced ejection fraction, and increased B-type natriuretic peptide level) became more prominent. Compared with the previous CHART-1 study, the prevalence of ischemic etiology and risk factors (hypertension, diabetes) have increased, as in Western studies. Conclusions: This first report demonstrates the trend of westernization of ischemic etiology and clinical characteristics of HF patients in Japan, indicating the importance of appropriate management and prevention of CAD to prevent AHFS.

Original languageEnglish
Pages (from-to)823-833
Number of pages11
JournalCirculation Journal
Volume75
Issue number4
DOIs
Publication statusPublished - 2011 Apr

Keywords

  • Coronary artery disease
  • Heart failure
  • Prognosis
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Trend of westernization of etiology and clinical characteristics of heart failure patients in Japan: First report from the CHART-2 Study'. Together they form a unique fingerprint.

  • Cite this