Trend in the study of cocaine addiction

Yoshiyuki Kasahara, Yosefu Arime, Asami Fukui, Osamu Uchiumi, Ichiro Sora

Research output: Contribution to journalReview articlepeer-review

Abstract

Psychostimulant drugs including cocaine increase extracellular levels of monoamines by blocking the neuronal plasma membrane transporters. Increased extracellular dopamine levels in mesocorticolimbic dopamine systems have been postulated to mediate the rewarding effects of cocaine. Studies in genetically modified mice models, particularly knockout mice have contributed a great deal to our understanding of the mechanisms underlying psychostimulant actions. Phenotypic analysis of genetically modified mice models has been instrumental in identifying the role of specific molecular targets of cocaine. In this article, we summarize studies that have reported the effects of cocaine using genetically modified mice especially gene knockouts of the monoamine transporters and receptors.

Original languageEnglish
Pages (from-to)1479-1485
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Volume68
Issue number8
Publication statusPublished - 2010 Aug
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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