Abstract
(matrix presented) In this Letter we demonstrate the viability of a highly stereoselective tandem Mannich cyclization-grammine fragmentation/addition cascade, critical for assembly of the A and F rings of penitrem D. We also explored simultaneous execution of this tactic with concurrent construction of ring I. Reinvestigation of a model system provided an explanation for the unanticipated stereochemical outcome at C(28).
Original language | English |
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Pages (from-to) | 1263-1266 |
Number of pages | 4 |
Journal | Organic letters |
Volume | 1 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1999 Oct 21 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry