Treatment outcomes of patients with FIGO Stage I/II uterine cervical cancer treated with definitive radiotherapy: A multi-institutional retrospective research study

Takuro Ariga, Takafumi Toita, Shingo Kato, Tomoko Kazumoto, Masaki Kubozono, Sunao Tokumaru, Hidehiro Eto, Tetsuo Nishimura, Yuzuru Niibe, Kensei Nakata, Yuko Kaneyasu, Takeshi Nonoshita, Takashi Uno, Tatsuya Ohno, Hiromitsu Iwata, Yoko Harima, Hitoshi Wada, Kenji Yoshida, Hiromichi Gomi, Hodaka NumasakiTeruki Teshima, Shogo Yamada, Takashi Nakano

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The purpose of this study was to analyze the patterns of care and outcomes of patients with FIGO Stage I/II cervical cancer who underwent definitive radiotherapy (RT) at multiple Japanese institutions. The Japanese Radiation Oncology Study Group (JROSG) performed a questionnaire-based survey of their cervical cancer patients who were treated with definitive RT between January 2000 and December 2005. A total of 667 patients were entered in this study. Although half of the patients were considered suitable for definitive RT based on the clinical features of the tumor, about one-third of the patients were prescribed RT instead of surgery because of poor medical status. The RT schedule most frequently utilized was whole-pelvic field irradiation (WP) of 30 Gy/15 fractions followed by WP with midline block of 20 Gy/10 fractions, and high-dose-rate intracavitary brachytherapy (HDR-ICBT) of 24 Gy/4 fractions prescribed at point A. Chemotherapy was administered to 306 patients (46%). The most frequent regimen contained cisplatin (CDDP). The median follow-up time for all patients was 65 months (range, 2-135 months). The 5-year overall survival (OS), pelvic control (PC) and disease-free survival (DFS) rates for all patients were 78%, 90% and 69%, respectively. Tumor diameter and nodal status were significant prognostic indicators for OS, PC and DFS. Chemotherapy has potential for improving the OS and DFS of patients with bulky tumors, but not for non-bulky tumors. This study found that definitive RT for patients with Stage I/II cervical cancer achieved good survival outcomes.

Original languageEnglish
Pages (from-to)841-848
Number of pages8
JournalJournal of radiation research
Volume56
Issue number5
DOIs
Publication statusPublished - 2015 Sep 1

Keywords

  • cervical cancer
  • early stage
  • radiotherapy

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

Fingerprint

Dive into the research topics of 'Treatment outcomes of patients with FIGO Stage I/II uterine cervical cancer treated with definitive radiotherapy: A multi-institutional retrospective research study'. Together they form a unique fingerprint.

Cite this