Treatment of refractory tardive dyskinesia with donepezil in an elderly patient with depression

Asuka Yoshimi, Takashi Togo, Naoya Sugiyama, Kumi Uehara, Tatsui Otsuka, Aya Karashima, Yoshio Hirayasu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Tardive dyskinesia (TD) is a neurological disorder caused by the prolonged administration of dopamine antagonists, usually antipsychotics and especially first-generation antipsychotics. Herein, we report on an elderly patient suffering from TD with depression induced by amoxapine, an antidepressant that antagonizes dopamine receptors. This case report demonstrates the therapeutic effect of donepezil even for TD due to amoxapine, corroborating the view that donepezil is beneficial for the treatment of TD induced by dopamine antagonists. A randomized placebo-controlled double-blind trial is required to confirm the usefulness of donepezil in the treatment of dopamine antagonist-induced TD.

Original languageEnglish
Pages (from-to)196-198
Number of pages3
Issue number4
Publication statusPublished - 2008
Externally publishedYes


  • Acetylcholinesterase
  • Donepezil
  • Involuntary movement
  • Oral dyskinesia
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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