Treatment of posttraumatic stress disorder using the traditional Japanese Herbal Medicine saikokeishikankyoto: A randomized, observer-blinded, controlled trial in survivors of the Great East Japan earthquake and tsunami

Takehiro Numata, Shen Gunfan, Shin Takayama, Satomi Takahashi, Yasutake Monma, Soichiro Kaneko, Hitoshi Kuroda, Junichi Tanaka, Seiki Kanemura, Masayuki Nara, Yutaka Kagaya, Tadashi Ishii, Nobuo Yaegashi, Masahiro Kohzuki, Koh Iwasaki

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The Great East Japan earthquake and tsunami caused immense damage over a wide area of eastern Japan. Hence, many survivors are at high risk for posttraumatic stress disorder (PTSD). This randomized, observer-blinded, controlled trial examined the efficacy and safety of the traditional Japanese herbal formula saikokeishikankyoto (SKK) in the treatment of PTSD among survivors of this disaster. Forty-three participants with an Impact of Event Scale-Revised (IES-R) score ≥ 25 were randomized into SKK (n=21) and control (n=22) groups. The primary endpoint was the change in IES-R scores from baseline till after 2 weeks of treatment. Intergroup statistical comparisons were performed. The magnitude of changes in total IES-R scores differed significantly between the two groups (P<0.001). Post hoc analysis showed that the total IES-R score improved significantly in the SKK group from 49.6 ± 11.9 to 25.5 ± 17.0 (P < 0.001). Subscale scores improved significantly in the SKK group (avoidance, P=0.003; hyperarousal, P<0.001; intrusion, P<0.001). Two-week treatment with SKK significantly improved IES-R scores among PTSD patients. This traditional medicine may be a valid choice for the treatment of psychological and physical symptoms in PTSD patients.

Original languageEnglish
Article number683293
JournalEvidence-based Complementary and Alternative Medicine
Volume2014
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Complementary and alternative medicine

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