Treatment of oral ranula in HIV-positive patient

Yusuke Kusano, Ryoukichi Ikeda, Yutaro Saito, Muneharu Yamazaki, Yutaka Tateda, Shiori Kitaya, Fumi Shoji, Takahiro Suzuki, Naoya Noguchi, Masafumi Seki, Nobuo Ohta

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


HIV-associated salivary gland disease refers to the pathology in head and neck lesions such as ranula, salivary gland swelling, xerostomia, and benign lymphoepithelial cysts in the parotid gland. Here, we present a unique case of the ranula patient with HIV infection treated with OK-423 sclerotherapy. Case report: The patient was a 42-year-old Japanese male with a few months history of oral floor swelling. Computed tomography (CT) showed a low-density area limited within the right floor of the mouth. Magnetic resonance imaging (MRI) revealed a distinct T2-high intensity area localized on the same location. The puncture fluid was bloody mucus, and the cytology was no malignancy. We diagnosed a simple ranula. He was, however, found to be HIV-antibody positive at the examination before treatment by chance. He was referred to the department of infectious diseases and definitively diagnosed HIV infection by western blot. We chose OK-432 sclerotherapy because of its minimally invasive and the risk of HIV infecting medical staff. Two times OK-432 injection made the lesion disappear. Conclusion: The case indicated that OK-432 sclerotherapy could be effective for ranula related to HIV.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalAuris Nasus Larynx
Issue number1
Publication statusPublished - 2021 Feb
Externally publishedYes


  • HIV-associated salivary gland disease
  • Human immunodeficiency virus (HIV)
  • OK-423 sclerotherapy
  • Ranula
  • Sclerotherapy

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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