Treatment of multiple sclerosis with anti-measles cow colostrum

T. Ebina, A. Sato, K. Umezu, H. Aso, N. Ishida, H. Seki, T. Tsukamoto, S. Takase, S. Hoshi, M. Ohta

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Previous virological and immunological studies have suggested that multiple sclerosis (MS) is an auto-immune disease triggered by a virus infection. In order to inhibit the growth of measles virus in the patient's jejunum, we obtained an IgA-rich cow colostrum containing anti-measles lactoglobulin resistant to proteases. This colostrum was orally administered to patients with MS to investigate its effect on the course of the disease. Measles-positive antibody colostrum was orally administered every morning to 15 patients with MS at a daily dosage of 100 ml for 30 days. Similarly, measles-negative antibody (< 8) control colostrum was orally administered to 5 patients. As a clinical assessment, disability scores developed by the International Federation of Multiple Sclerosis Societies were used. As a result, of 7 high NT titre (512-5120) anti-measles colostrum recipients 5 patients improved and 2 remained unchanged. Among 8 low NT titre (8-32) anti-measles colostrum recipients 5 patients improved and 3 remained unchanged. However, of 5 negative NT titre (< 8) colostrum recipients 2 patients remained unchanged and 3 worsened. No side-effects were observed in colostrum recipients. These findings suggest the efficacy of orally administered anti-measles colostrum in improving the condition of MS patients (P < 0.05).

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalMedical Microbiology and Immunology
Volume173
Issue number2
DOIs
Publication statusPublished - 1984 Sep

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Microbiology (medical)

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  • Cite this

    Ebina, T., Sato, A., Umezu, K., Aso, H., Ishida, N., Seki, H., Tsukamoto, T., Takase, S., Hoshi, S., & Ohta, M. (1984). Treatment of multiple sclerosis with anti-measles cow colostrum. Medical Microbiology and Immunology, 173(2), 87-93. https://doi.org/10.1007/BF02124822